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Instrumental Methods of Analysis Notes

Instrumental methods of analysis refer to a group of techniques used to analyse samples and quantify their components. These methods rely on instruments to measure physical properties of the sample such as absorption, emission, or mass. Here are some of the most common instrumental methods of analysis:

Spectroscopy: Spectroscopy involves the study of the interaction of electromagnetic radiation with matter. This technique is used to measure the absorption, emission, or scattering of light by a sample. There are many different types of spectroscopy, including ultraviolet-visible (UV-Vis), infrared (IR), Raman, and nuclear magnetic resonance (NMR) spectroscopy.

Chromatography: Chromatography is a technique used to separate the components of a mixture. This method involves passing the mixture through a stationary phase, which separates the components based on their physical and chemical properties. There are several types of chromatography, including gas chromatography (GC), liquid chromatography (LC), and ion chromatography (IC).

Mass spectrometry: Mass spectrometry is a technique used to determine the molecular mass and composition of a sample. This method involves ionising the sample and then separating the ions based on their mass-to-charge ratio.

Electrochemical methods: Electrochemical methods involve the measurement of electrical properties of a sample, such as its conductivity, potential, or current. These methods are often used to analyse samples containing electrolytes, such as solutions of ions or metals.

Thermal methods: Thermal methods involve the measurement of the heat released or absorbed by a sample. This technique is used to determine the enthalpy, entropy, or heat capacity of a sample.

X-ray diffraction: X-ray diffraction is a technique used to study the crystal structure of a sample. This method involves passing X-rays through the sample and measuring the diffraction pattern that results.

Overall, instrumental methods of analysis have revolutionised the way we analyse and quantify samples. These techniques have significantly increased the sensitivity, accuracy, and speed of chemical analysis, making them invaluable tools in research, development, and quality control.

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